Spokes R A, Yiangou Y, Chrysanthou B J, Bowles M P, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Gastroenterology. 1989 Feb;96(2 Pt 1):327-30. doi: 10.1016/0016-5085(89)91555-2.
Intravenous infusion of low doses of vasoactive intestinal polypeptide, peptide histidine valine-42, and peptide histidine methionine (and the rat equivalent, peptide histidine isoleucine) into anesthetized rats caused a reduction in net absorption of fluid from the small intestine. Larger doses caused a net fluid secretion. At the same nominal infusion rates, peptide histidine valine-42 appeared to be the most potent. In terms of plasma concentrations achieved, however, vasoactive intestinal polypeptide was approximately six times more active than the other two human peptides. If confirmed in humans, these results would suggest that peptide histidine methionine and peptide histidine valine may be as important as vasoactive intestinal polypeptide in causing the watery diarrhea seen in the Verner-Morrison syndrome in which plasma levels of all three peptides are raised.
向麻醉的大鼠静脉输注低剂量的血管活性肠肽、组氨酸-缬氨酸-42肽和组氨酸-甲硫氨酸肽（以及大鼠等效物组氨酸-异亮氨酸肽）会导致小肠液体净吸收减少。较大剂量则会导致液体净分泌。在相同的名义输注速率下，组氨酸-缬氨酸-42肽似乎最有效。然而，就达到的血浆浓度而言，血管活性肠肽的活性约为其他两种人肽的六倍。如果在人体中得到证实，这些结果将表明，在导致韦纳-莫里森综合征中出现的水样腹泻方面，组氨酸-甲硫氨酸肽和组氨酸-缬氨酸肽可能与血管活性肠肽一样重要，在该综合征中所有这三种肽的血浆水平都会升高。
