School of Pharmacy, International Medical University, 126, Jln Jalil Perkasa 19, Bukit Jalil, 57000 Wilayah Persekutuan Kuala Lumpur, Malaysia.
School of Pharmacy, International Medical University, 126, Jln Jalil Perkasa 19, Bukit Jalil, 57000 Wilayah Persekutuan Kuala Lumpur, Malaysia.
Drug Discov Today. 2018 Mar;23(3):460-480. doi: 10.1016/j.drudis.2017.10.020. Epub 2017 Oct 28.
MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression at the post-translational level. miRNA-based therapeutic agents are important because of the functionality of miRNAs in regulating lipid and glucose metabolism and their role in the pathogenesis of metabolic disorders such as diabetes and obesity, where dysregulation leads to disease; they are also important in angiogenesis. miRNAs additionally serve as biomarkers in the diagnosis, prognosis and risk assessment of disease and in monitoring the response to treatment. Here, we provide a brief overview of progress in miRNA-based therapeutics in the preclinical and clinical setting and highlight the novel outcomes and opportunities in the diagnosis and treatment of metabolic conditions. In addition, we present the role of miRNAs in stem cell therapy which could have great potential in regenerative medicine.
微小 RNA（miRNAs）是一种小的非编码 RNA，可在翻译后水平调节基因表达。基于 miRNA 的治疗剂很重要，因为 miRNA 具有调节脂质和葡萄糖代谢的功能，并且在代谢紊乱（如糖尿病和肥胖症）的发病机制中发挥作用，其中失调会导致疾病；它们在血管生成中也很重要。miRNAs 还可作为疾病诊断、预后和风险评估以及监测治疗反应的生物标志物。在这里，我们简要概述了 miRNA 治疗在临床前和临床环境中的进展，并强调了代谢疾病诊断和治疗的新成果和机会。此外，我们还介绍了 miRNA 在干细胞治疗中的作用，这在再生医学中可能具有巨大的潜力。
