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Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.

作者信息

Fernández Nicolás, Olivera Nancy Mónica, Keller Guillermo Alberto, Diez Roberto Alberto, Di Girolamo Guillermo, Quiroga Patricia Noemí

出版信息

Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):2056. doi: 10.1002/rcm.7976.

DOI:10.1002/rcm.7976
PMID:29108129
Abstract
摘要

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Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.采用固相萃取和气相色谱/质谱联用技术同时定量测定人血浆中的哌替啶、去甲哌替啶、曲马多、丙氧芬和去甲丙氧芬：方法验证及其在治疗剂量心血管安全性研究中的应用
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