Sigurdsson K, Adalsteinsson S, Tulinius H, Ragnarsson J
Cancer Detection Clinic, Icelandic Cancer Society, Reykjavik.
Int J Cancer. 1989 Jan 15;43(1):1-5. doi: 10.1002/ijc.2910430102.
The effect of screening for cervical cancer on time trends in incidence and mortality from that disease, and the occurrence of pre-invasive cervical lesions during the period 1964-1986, were analyzed. After commencement of screening in 1964 all the above parameters increased for a short initial period but then fell markedly. From 1980, coinciding with a sharp rise in regular attendance rate, there was an increase in incidence up to 1984, followed by a decrease. The rate of pre-invasive stages also increased from 1980, but appears to be levelling off. The cervical cancer mortality rate decreased significantly during the study period. In more recent years, a shift in the occurrence of cervical cancer and pre-invasive lesions from older to younger women has been observed. Screening still appears to be effective in the control of squamous-cell carcinomas of stages I B and over, but not of adeno- and adenosquamous carcinomas.
分析了宫颈癌筛查对1964 - 1986年期间该疾病发病率和死亡率的时间趋势以及宫颈浸润前病变发生情况的影响。1964年开始筛查后,上述所有参数在最初的短时间内有所上升,但随后显著下降。从1980年开始,随着定期筛查率的急剧上升,发病率在1984年之前上升,随后下降。浸润前阶段的发生率也从1980年开始上升,但似乎趋于平稳。在研究期间,宫颈癌死亡率显著下降。近年来,已观察到宫颈癌和浸润前病变的发生从老年女性向年轻女性转移。筛查似乎仍能有效控制ⅠB期及以上的鳞状细胞癌,但对腺癌和腺鳞癌无效。