Devinsky O, Sato S, Theodore W H, Porter R J
Division of Intramural Research, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md.
J Clin Psychiatry. 1989 Jan;50(1):28-30.
The authors present the case of a 13-year-old girl with episodes characterized by either staring with preserved consciousness or fear in whom functional illness was suspected. Video-EEG telemetry revealed no changes during 30 of 32 attacks. Subdural electrode recordings revealed epileptiform discharges in 30 of 37 episodes. The discharge was always localized to the electrodes recording from the inferomedial temporal region, with electrodes over the lateral convexity of the same temporal lobe showing no background changes. Although the detailed pathophysiology of panic attacks remains to be clarified, the authors point out that their case and other epileptic case studies are consistent with the possibility that excessive neuronal activity in medial temporal lobe structures is a necessary element of the underlying mechanism.
作者报告了一名13岁女孩的病例，其发作表现为意识保留的凝视或恐惧，怀疑为功能性疾病。视频脑电图遥测显示，32次发作中有30次期间无变化。硬膜下电极记录显示，37次发作中有30次出现癫痫样放电。放电总是局限于记录颞叶内下区域的电极，而同一颞叶外侧凸面的电极未显示背景变化。尽管惊恐发作的详细病理生理学仍有待阐明，但作者指出，他们的病例和其他癫痫病例研究一致表明，颞叶内侧结构中神经元活动过度可能是潜在机制的必要因素。
