Brainnetome Center,Institute of Automation,Chinese Academy of Sciences,Beijing,China.
Peking University Clinical Research Institute,Peking University Health Science Center,Beijing,China.
Psychol Med. 2018 Jun;48(8):1381-1389. doi: 10.1017/S0033291717003130. Epub 2017 Nov 7.
High-sensitivity C-reactive protein (hs-CRP) has been suggested to be involved in the process of cognitive decline. However, the results from previous studies exploring the relationship between hs-CRP concentration and cognitive decline are inconsistent.
We employed data from wave 2 (2004-2005) to wave 7 (2014-2015) of the English Longitudinal Study of Ageing. Cognitive function was assessed at baseline (wave 2) and reassessed biennially at waves 3-7.
A total of 5257 participants (54.9% women, mean age 65.4 ± 9.4 years) with baseline hs-CRP levels ranged from 0.2 to 210.0 mg/L (median: 2.0 mg/L, interquartile range: 0.9-4.1 mg/L) were studied. The mean follow-up duration was 8.1 ± 2.8 years, and the mean number of cognitive assessment was 4.9 ± 1.5. Linear mixed models show that a one-unit increment in natural log-transformed hs-CRP was associated with faster declines in global cognitive scores [-0.048 points/year, 95% confidence interval (CI) -0.072 to -0.023], memory scores (-0.022 points/year, 95% CI -0.031 to -0.013), and executive function scores (-0.025 points/year, 95% CI -0.043 to -0.006), after multivariable adjustment. Compared with the lowest quartile of hs-CRP, the multivariable-adjusted rate of global cognitive decline associated with the second, third, and highest quartile was faster by -0.043 points/year (95% CI -0.116 to 0.029), -0.090 points/year (95% CI -0.166 to -0.015), -0.145 (95% CI -0.221 to -0.069), respectively (p for trend <0.001). Similarly, memory and executive function also declined faster with increasing quartiles of hs-CRP.
A significant association between hs-CRP concentration and long-term cognitive decline was observed in this study. Hs-CRP might serve as a biomarker for cognitive decline.
高敏 C 反应蛋白（hs-CRP）已被认为参与认知能力下降的过程。然而，先前研究 hs-CRP 浓度与认知能力下降之间关系的结果并不一致。
我们利用英国老龄化纵向研究第 2 波（2004-2005 年）至第 7 波（2014-2015 年）的数据。认知功能在基线（第 2 波）进行评估，并在第 3-7 波进行每两年一次的重新评估。
共纳入了 5257 名基线 hs-CRP 水平为 0.2-210.0 mg/L（中位数：2.0 mg/L，四分位距：0.9-4.1 mg/L）的参与者（54.9%为女性，平均年龄 65.4±9.4 岁）。平均随访时间为 8.1±2.8 年，平均认知评估次数为 4.9±1.5。线性混合模型显示，自然对数转换后的 hs-CRP 每增加 1 个单位，全球认知评分的下降速度就会加快[-0.048 分/年，95%置信区间（CI）-0.072 至-0.023]、记忆评分[-0.022 分/年，95% CI -0.031 至-0.013]和执行功能评分[-0.025 分/年，95% CI -0.043 至-0.006]，经多变量调整后。与 hs-CRP 最低四分位数相比，第二、第三和最高四分位数与全球认知下降相关的多变量调整后率分别加快了-0.043 分/年（95% CI -0.116 至 0.029）、-0.090 分/年（95% CI -0.166 至 -0.015）、-0.145 分/年（95% CI -0.221 至 -0.069）（p 值趋势<0.001）。同样，记忆和执行功能也随着 hs-CRP 四分位数的增加而下降得更快。
在这项研究中，观察到 hs-CRP 浓度与长期认知能力下降之间存在显著关联。hs-CRP 可能是认知能力下降的生物标志物。
