Hachiya Mami, Satoh Kenichi, Takami Shinichiro, Uetake Shinichiro, Arihiro Seiji, Hokari Atsushi, Ishikawa Tomohisa, Takagi Ichiro, Tajiri Hisao, Saruta Masayuki
Department of Gastroenterology and Hepatology, The Jikei University School of Medicine.
Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 2017;114(11):1978-1986. doi: 10.11405/nisshoshi.114.1978.
Metastasis of uveal melanoma of the digestive tract is rare. We report a case of a patient with metastatic uveal melanoma of the liver and digestive tract. A 68-year-old man was admitted with primary complaint of appetite loss and fatigue. Abdominal computed tomography revealed a 13-cm diameter tumor in the right lobe of the liver. We diagnosed him with metastatic uveal melanoma. We performed a liver tumor biopsy and diagnosed metastatic melanoma;we found distant metastases in the stomach, duodenum, and rectum on endoscopic biopsy. We administered systemic chemotherapy [DACa-Tam therapy (Dacarbazine, 220mg/m×3 days;Nimustine, 60mg/m×1 day;Carboplatin area under the curve (AUC) =4×1 day;Tamoxifen, 40mg/day×3 days)]. Prognosis is unfavorable in approximately half of the patients with liver metastases that occur through blood circulation. The patient died of liver failure two months after the diagnosis.
