College of Pharmacy, Dalian Medical University, Dalian 116044，China.
Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, China.
Nutrients. 2017 Oct 29;9(11):1188. doi: 10.3390/nu9111188.
Resveratrol, a natural phytoalexin, exhibits a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. However, the therapeutic application of resveratrol was encumbered for its low bioavailability. Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol. During the past decades, a large number of natural and synthetic resveratrol derivatives were extensively studied, and the methoxylated, hydroxylated and halogenated derivatives of resveratrol received particular more attention for their beneficial bioactivity. So, in this review, we will summarize the chemical structure and the therapeutic versatility of resveratrol derivatives, and thus provide the related structure activity relationship reference for their practical applications.
白藜芦醇是一种天然的植物抗毒素，具有显著的生物活性，如抗癌、心脏保护、神经保护和抗氧化作用。然而，由于其生物利用度低，白藜芦醇的治疗应用受到了阻碍。因此，许多研究人员专注于设计和合成白藜芦醇的衍生物，以提高白藜芦醇的生物利用度和药理活性。在过去的几十年中，大量的天然和合成白藜芦醇衍生物得到了广泛的研究，而白藜芦醇的甲氧基化、羟基化和卤化衍生物因其有益的生物活性而受到特别关注。因此，在这篇综述中，我们将总结白藜芦醇衍生物的化学结构和治疗多样性，为其实际应用提供相关的结构活性关系参考。
