Liu Shan-Shan, Dai Yun-Tao, Sui Feng, Chen Liang-Mian, Yan Li-Hua, Zhang Qi-Wei, Wang Zhi-Min
a Institute of Chinese Materia Medica , China Academy of Chinese Medical Sciences , Beijing 100700 , China.
b National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines , Beijing 100700 , China.
J Asian Nat Prod Res. 2018 Sep;20(9):867-874. doi: 10.1080/10286020.2017.1399881. Epub 2017 Nov 7.
Two new flavonol glycosides, limocitrin 3-O-β-D-xylopyranosyl(1→2)-β-D-glucopyranoside (1) and limocitrin 3-O[2-O-β-D-xylopyranosyl-6-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2), together with eight known analogs (3-10), were isolated from the fruits of Evodia rutaecarpa. Their structures were elucidated on the basis of spectroscopic analyses and chemical evidences. Meanwhile, Nrf2 inducing abilities of seven isolated compounds were evaluated, and compounds 1, 2, 6, 7, and 8 exhibited moderate effect on Nrf2.
从吴茱萸果实中分离得到两个新的黄酮醇苷，即黎檬素3 - O - β - D - 吡喃木糖基(1→2)-β - D - 吡喃葡萄糖苷（1）和黎檬素3 - O[2 - O - β - D - 吡喃木糖基 - 6 - O - α - L - 吡喃鼠李糖基]-β - D - 吡喃葡萄糖苷（2），以及八个已知类似物（3 - 10）。通过光谱分析和化学证据对它们的结构进行了阐明。同时，评估了七种分离化合物的Nrf2诱导能力，化合物1、2、6、7和8对Nrf2表现出中等程度的作用。
