漆树酸通过抑制组蛋白乙酰化减少人分化脂肪细胞中的脂肪生成。 - Suppr

Anacardic acid reduces lipogenesis in human differentiated adipocytes via inhibition of histone acetylation.

作者信息

Kim Min-Kyoung, Kim Eun Ju, Kim Ji Eun, Lee Dong Hun, Chung Jin Ho

机构信息

Department of Dermatology, Seoul National University College of Medicine, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Republic of Korea.

出版信息

J Dermatol Sci. 2018 Jan;89(1):94-97. doi: 10.1016/j.jdermsci.2017.10.004. Epub 2017 Oct 18.

DOI:10.1016/j.jdermsci.2017.10.004

PMID:29111182

Abstract

摘要

相似文献

Anacardic acid reduces lipogenesis in human differentiated adipocytes via inhibition of histone acetylation.漆树酸通过抑制组蛋白乙酰化减少人分化脂肪细胞中的脂肪生成。

J Dermatol Sci. 2018 Jan;89(1):94-97. doi: 10.1016/j.jdermsci.2017.10.004. Epub 2017 Oct 18.

Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT.组蛋白乙酰转移酶（HAT）P300/CBP 抑制剂通过使 AKT 不稳定在 PTEN 缺陷的结直肠癌细胞中诱导合成致死性。

Int J Biol Sci. 2020 Mar 25;16(11):1774-1784. doi: 10.7150/ijbs.42197. eCollection 2020.

Anacardic acid ameliorates ultraviolet irradiation-induced damage to human skin.漆树酸可改善紫外线照射对人体皮肤造成的损伤。

J Dermatol Sci. 2017 Jun;86(3):252-255. doi: 10.1016/j.jdermsci.2017.03.019. Epub 2017 Mar 30.

Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts.在发育中的小鼠心脏中，组蛋白乙酰化酶抑制剂漆树酸可逆转酒精诱导的组蛋白H3K9高乙酰化和心脏肥大。

Biochimie. 2015 Jun;113:1-9. doi: 10.1016/j.biochi.2015.03.012. Epub 2015 Mar 20.

Histone acetyltransferase p300 is induced by p38MAPK after photodynamic therapy: the therapeutic response is increased by the p300HAT inhibitor anacardic acid.光动力治疗后 p38MAPK 诱导组蛋白乙酰转移酶 p300：p300HAT 抑制剂芒果苷可增加治疗反应。

Free Radic Biol Med. 2015 Sep;86:118-32. doi: 10.1016/j.freeradbiomed.2015.05.009. Epub 2015 May 19.

Critical role of histone acetylation by p300 in human placental 11β-HSD2 expression.p300 介导的组蛋白乙酰化在人胎盘 11β-HSD2 表达中的关键作用。

J Clin Endocrinol Metab. 2013 Jul;98(7):E1189-97. doi: 10.1210/jc.2012-4291. Epub 2013 May 28.

Topical application of anacardic acid (6-nonadecyl salicylic acid) reduces UV-induced histone modification, MMP-13, MMP-9, COX-2 and TNF-α expressions in hairless mice skin.使用没食子酸（6-十九烷基水杨酸）进行局部涂抹可降低无毛小鼠皮肤中紫外线诱导的组蛋白修饰、基质金属蛋白酶-13（MMP-13）、基质金属蛋白酶-9（MMP-9）、环氧化酶-2（COX-2）和肿瘤坏死因子-α（TNF-α）的表达。

J Dermatol Sci. 2013 Apr;70(1):64-7. doi: 10.1016/j.jdermsci.2012.11.008. Epub 2012 Nov 23.

Use of histone deacetylase inhibitors to examine the roles of bromodomain and histone acetylation in p300-dependent gene expression.使用组蛋白去乙酰化酶抑制剂来研究溴结构域和组蛋白乙酰化在p300依赖性基因表达中的作用。

Methods Mol Biol. 2013;977:353-7. doi: 10.1007/978-1-62703-284-1_28.

Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells.漆树酸衍生物抑制 PCAF 导致表达 BCR-ABL 的细胞凋亡和破坏对 DNA 损伤的耐药性。

Anticancer Agents Med Chem. 2013 Jun;13(5):762-7. doi: 10.2174/1871520611313050010.

Inhibition of DNA Methylation in the COL1A2 Promoter by Anacardic Acid Prevents UV-Induced Decrease of Type I Procollagen Expression.漆树酸对COL1A2启动子DNA甲基化的抑制作用可防止紫外线诱导的I型前胶原表达降低。

J Invest Dermatol. 2017 Jun;137(6):1343-1352. doi: 10.1016/j.jid.2017.02.005. Epub 2017 Feb 24.

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Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence.表观遗传调控下脂肪基因的动态呈现：揭示肥胖发生的新机制

Curr Issues Mol Biol. 2025 Jul 11;47(7):540. doi: 10.3390/cimb47070540.

Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome.蛋白质赖氨酸乙酰化在肥胖症和代谢综合征发病机制及治疗中的作用

Curr Obes Rep. 2025 Mar 13;14(1):24. doi: 10.1007/s13679-025-00615-1.

Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95.组蛋白去乙酰化酶 1 通过抑制人皮脂腺细胞系 SZ95 中的 SREBP1 转录来减少脂肪生成。

Int J Mol Sci. 2021 Apr 25;22(9):4477. doi: 10.3390/ijms22094477.

Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation.简明综述：间充质干细胞分化过程中赖氨酸乙酰化的调控机制

Stem Cells Int. 2020 Jan 28;2020:7618506. doi: 10.1155/2020/7618506. eCollection 2020.

Anacardic acid mitigates liver fat accumulation and impaired glucose tolerance in mice fed a high-fat and high-sucrose diet.在喂食高脂高糖饮食的小鼠中，漆树酸可减轻肝脏脂肪堆积和葡萄糖耐量受损的情况。

Food Sci Nutr. 2020 Jan 17;8(2):796-804. doi: 10.1002/fsn3.1322. eCollection 2020 Feb.

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Anacardic acid reduces lipogenesis in human differentiated adipocytes via inhibition of histone acetylation.

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