Quimby S R, Gibson L E, Winkelmann R K
Department of Dermatology, Mayo Clinic Scottsdale, AZ 85259.
Mayo Clin Proc. 1989 Jan;64(1):37-43. doi: 10.1016/s0025-6196(12)65301-4.
Superficial granulomatous pyoderma is a form of pyoderma gangrenosum characterized by superficial ulceration and a chronic course. Histopathologic examination shows a granulomatous response. We report two new cases of superficial granulomatous pyoderma in detail and briefly review the clinical data of five previous cases included in a recent series. These lesions typically begin as single furunculoid papules that most commonly occur on the trunk and that may arise at sites of surgical treatment or other pathergic stimuli. The lesions progress to superficial ulcers with a relatively clean base and vegetative borders. Tetracycline, minocycline, sulfapyridine, dapsone, and intralesionally administered corticosteroids have been effective anti-inflammatory agents, producing healing and allowing avoidance of the use of systemic corticosteroids in the management of most patients with superficial granulomatous pyoderma.
浅表性肉芽肿性脓皮病是坏疽性脓皮病的一种形式，其特征为浅表溃疡和慢性病程。组织病理学检查显示为肉芽肿反应。我们详细报告了2例新的浅表性肉芽肿性脓皮病病例，并简要回顾了最近一系列研究中纳入的5例既往病例的临床资料。这些损害通常起始为单个疖样丘疹，最常见于躯干，可能出现在手术治疗部位或其他激发性刺激部位。损害进展为具有相对清洁基底和增殖性边缘的浅表溃疡。四环素、米诺环素、磺胺吡啶、氨苯砜以及皮损内注射皮质类固醇一直是有效的抗炎药物，可促使愈合，并使大多数浅表性肉芽肿性脓皮病患者在治疗过程中避免使用全身性皮质类固醇。
