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失代偿期肝硬化的姑息治疗:综述。

Palliative care in decompensated cirrhosis: A review.

机构信息

Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

VA Connecticut Healthcare System, West Haven, CT, USA.

出版信息

Liver Int. 2018 May;38(5):768-775. doi: 10.1111/liv.13620. Epub 2018 Jan 15.

Abstract

Decompensated cirrhosis is an illness that causes tremendous suffering. The incidence of cirrhosis is increasing and rates of liver transplant, the only cure, remain stagnant. Palliative care is focused on improving quality of life for patients with serious illness by addressing advanced care planning, alleviating physical symptoms and providing emotional support to the patient and family. Palliative care is used infrequently in patients with decompensated cirrhosis. The allure of transplant as a potential treatment option for cirrhosis, misperceptions about the role of palliative care and difficulty predicting prognosis in liver disease are potential contributors to the underutilization of palliative care in this patient population. Studies have demonstrated some benefit of palliative care in patients with decompensated cirrhosis but the literature is limited to small observational studies. There is evidence that palliative care consultation in other patient populations lowers hospital costs and ICU utilization and improves symptom control and patient satisfaction. Prospective randomized control trials are needed to investigate the effects of palliative care on traditional- and patient-reported outcomes as well as cost of care in decompensated cirrhosis for transplant eligible and ineligible patient populations.

摘要

失代偿期肝硬化是一种会带来极大痛苦的疾病。肝硬化的发病率正在上升,而肝移植的比例(唯一的治疗方法)却保持停滞。姑息治疗专注于通过解决先进的护理计划、缓解身体症状以及为患者和家属提供情感支持来提高患有严重疾病患者的生活质量。姑息治疗在失代偿期肝硬化患者中应用较少。移植作为肝硬化潜在治疗选择的吸引力、对姑息治疗作用的误解以及预测肝病预后的困难,是导致该患者群体姑息治疗利用率低的潜在因素。研究表明姑息治疗对失代偿期肝硬化患者有一定益处,但文献仅限于小型观察性研究。有证据表明,姑息治疗咨询在其他患者群体中可以降低医院成本和 ICU 利用率,并改善症状控制和患者满意度。需要前瞻性随机对照试验来研究姑息治疗对传统和患者报告的结果以及适合和不适合移植的失代偿期肝硬化患者群体的护理成本的影响。

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