Jauniaux E, Donner C, Simon P, Vanesse M, Hustin J, Rodesch F
Department of Obstetrics and Gynecology, Hôpital Universitaire Erasme, Free University of Brussels, Belgium.
Obstet Gynecol. 1989 Feb;73(2):215-8.
Percutaneous umbilical blood sampling (cordocentesis) appears to be a valuable new procedure for prenatal diagnosis. In order to evaluate whether focal injury of the umbilical vessels caused by the needle puncture is potentially harmful, we completely examined 50 umbilical cords collected between 1 hour and 20 weeks after cordocentesis. Macroscopic evidence of the needle entry was found in 37 cases, including one giant hematoma of the cord. Within 48 hours after the procedure, microscopic examination of transverse sections taken at the puncture site revealed distinct perforation of the vessel wall, associated in four cases with a small hematoma encircling the vessel. One week after cordocentesis, the vessel wall was partially reformed. There were no histologic differences between needle entry in a vein or in an artery. No thromboses of the umbilical vessels were found.
经皮脐血采样（脐带穿刺术）似乎是一种有价值的产前诊断新方法。为了评估针刺造成的脐血管局部损伤是否有潜在危害，我们对脐带穿刺术后1小时至20周内收集的50条脐带进行了全面检查。在37例中发现了针进入的宏观证据，其中包括1例脐带巨大血肿。术后48小时内，对穿刺部位横切面的显微镜检查显示血管壁有明显穿孔，4例伴有围绕血管的小血肿。脐带穿刺术后1周，血管壁部分重塑。静脉或动脉穿刺在组织学上没有差异。未发现脐血管血栓形成。
