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硬左房综合征相关肺动脉高压:一种发病机制和一种治疗方法。

Pulmonary hypertension in stiff left atrial syndrome: pathogenesis and treatment in one.

机构信息

Cardiology Department, Kantonsspital St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland.

Department of Internal Medicine, Spital Grabs, Grabs, Switzerland.

出版信息

ESC Heart Fail. 2018 Feb;5(1):189-192. doi: 10.1002/ehf2.12234. Epub 2017 Nov 8.

DOI:10.1002/ehf2.12234
PMID:29115016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5793980/
Abstract

We present the rare case of a patient with pulmonary hypertension in the context of the stiff left atrial syndrome after extensive catheter ablation, a unique constellation characterized by high pulmonary artery and pulmonary artery wedge pressures due to left atrial dysfunction but normal left ventricular end-diastolic pressure, normal mitral valve, and absence pulmonary vein stenosis. This patient was surprisingly oligosymptomatic, however, which may have been due to a persistent post-puncture atrial septal defect, which may have allowed for controlled left atrial decompression, which is in line with the novel concept of the catheter-based creation of an intracardiac shunt as a treatment for heart failure.

摘要

我们报告了一例罕见病例,该患者在广泛导管消融术后出现左心房僵硬综合征相关肺动脉高压,其特征为左心房功能障碍导致肺动脉和肺动脉楔压升高,但左心室舒张末期压正常、二尖瓣正常且无肺静脉狭窄。然而,该患者症状出奇地少,这可能是由于持续性穿刺后房间隔缺损,这可能允许左心房减压得到控制,这与经导管创建心内分流作为心力衰竭治疗的新概念一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9fa/5793980/531282f6d9cf/EHF2-5-189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9fa/5793980/f5b0ace23901/EHF2-5-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9fa/5793980/531282f6d9cf/EHF2-5-189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9fa/5793980/f5b0ace23901/EHF2-5-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9fa/5793980/531282f6d9cf/EHF2-5-189-g002.jpg

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本文引用的文献

1
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Circ Heart Fail. 2017 Jul;10(7). doi: 10.1161/CIRCHEARTFAILURE.117.004160.
2
Stiff Left Atrial Syndrome After Multiple Percutaneous Catheter Ablations: Role for Invasive Hemodynamic Exercise Testing.多次经皮导管消融术后的僵硬左心房综合征:有创血流动力学运动试验的作用
Circ Heart Fail. 2017 May;10(5):e003885. doi: 10.1161/CIRCHEARTFAILURE.117.003885.
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Pulmonary hypertension associated with left-sided heart disease.与左心疾病相关的肺动脉高压。
左心房顺应性:二尖瓣狭窄或房颤患者接受侵入性治疗时临床结局的一个被忽视的预测指标。
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A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial.经导管左心室内分流装置治疗射血分数保留的心力衰竭(REDUCE LAP-HF):一项多中心、开放标签、单臂、1 期试验。
Lancet. 2016 Mar 26;387(10025):1298-304. doi: 10.1016/S0140-6736(16)00704-2.
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Stiff Left Atrial Syndrome: A Complication Undergoing Radiofrequency Catheter Ablation for Atrial Fibrillation.僵硬左心房综合征:心房颤动射频导管消融术的一种并发症
J Cardiovasc Electrophysiol. 2016 Jul;27(7):884-9. doi: 10.1111/jce.12966. Epub 2016 Apr 14.
6
Severely worsening dyspnea after initiation of macitentan therapy for pulmonary arterial hypertension.在开始使用马昔腾坦治疗肺动脉高压后,呼吸困难严重恶化。
Int J Cardiol. 2016 Jan 1;202:244-5. doi: 10.1016/j.ijcard.2015.08.132. Epub 2015 Sep 14.
7
Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure.经导管治疗射血分数保留或轻度降低的心衰:使用新型房间隔植入物降低左心房压力。
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9
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J Am Coll Cardiol. 2010 Sep 7;56(11):855-63. doi: 10.1016/j.jacc.2010.04.040.