Schmiedl U, Sievers R E, Brasch R C, Wolfe C L, Chew W M, Ogan M D, Engeseth H, Lipton M J, Moseley M E
Contrast Media Laboratory, University of California School of Medicine, San Francisco 94143-0628.
Radiology. 1989 Feb;170(2):351-6. doi: 10.1148/radiology.170.2.2911657.
The utility of a macromolecular, intravascular contrast agent, albumin-gadolinium diethylenetriaminepentaacetic acid (DTPA), for the differentiation of acutely ischemic and reperfused myocardium on magnetic resonance (MR) images was investigated. Regional, reversible myocardial ischemia was produced in rats and confirmed. After reperfusion, flow to the compromised myocardial segment returned to baseline. Normal myocardium could not be differentiated from ischemic myocardium on nonenhanced MR images (n = 12). After 5 minutes of myocardial ischemia and after administration of albumin-Gd-DTPA, the ischemic zone involving the free wall of the left ventricle was characterized by the absence of significant enhancement. Normal myocardium appeared homogeneously enhanced (by 145%). This pattern persisted for up to 1 hour of myocardial ischemia. In six rats that underwent myocardial reperfusion after 5 minutes of ischemia, the normal and reperfused myocardium became isointense. Radiotracer studies with albumin-Gd-153-DTPA confirmed the decreased distribution of contrast agent to the ischemic myocardium, possibly due to decreased blood pool or a blocked primary delivery system in the ischemic myocardium.
研究了一种大分子血管内造影剂——白蛋白钆二乙三胺五乙酸（DTPA）在磁共振（MR）图像上鉴别急性缺血和再灌注心肌的效用。在大鼠中制造并证实了局部可逆性心肌缺血。再灌注后，受损心肌节段的血流恢复至基线水平。在未增强的MR图像上（n = 12），正常心肌与缺血心肌无法区分。在心肌缺血5分钟后并给予白蛋白钆-DTPA后，累及左心室游离壁的缺血区表现为无明显强化。正常心肌呈均匀强化（强化145%）。这种模式在心肌缺血长达1小时内持续存在。在6只缺血5分钟后进行心肌再灌注的大鼠中，正常心肌和再灌注心肌变得等信号。用白蛋白钆-153-DTPA进行的放射性示踪研究证实，造影剂在缺血心肌中的分布减少，这可能是由于血池减少或缺血心肌中的主要输送系统受阻所致。
