NLRP3 多态性与多发性硬化症患者对干扰素-β的反应。
NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.
机构信息
Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
出版信息
Mult Scler. 2018 Oct;24(11):1507-1510. doi: 10.1177/1352458517739137. Epub 2017 Nov 9.
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
我们旨在探究富含 N 端亮氨酸重复蛋白家族成员 3（NLRP3）多态性是否与多发性硬化症（MS）患者对干扰素-β（IFNβ）的反应相关。在一个由 5 个中心招募的 665 例复发缓解型 MS 患者队列中，共对 14 个 NLRP3 多态性进行了基因分型，并根据 IFNβ治疗 1 年后的临床放射学标准将其分为应答者和非应答者。荟萃分析未能显示 NLRP3 多态性与 IFNβ 应答之间存在显著关联。这些发现不支持 NLRP3 基因多态性与 MS 患者对 IFNβ 的反应之间存在相关性。
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