Li Chengzhen, He Ying, Ma Haijing, Han Seongho
Department of Family Medicine, College of Medicine, Dong-A UniversityBusan 604-714, Republic of Korea.
Department of Emergency, Heilongjiang Provincial HospitalHarbin 150000, Heilongjiang, China.
Am J Transl Res. 2017 Oct 15;9(10):4450-4457. eCollection 2017.
Osteosarcoma is one of the most common bone tumors in young patients. NOVA1 (neuro-oncological ventral antigen 1) is a neuron-specific RNA binding-protein and belongs to the Nova family. Previous studies showed that NOVA1 played crucial roles in the development of several tumors. The objective of our study was to study the role of NOVA1 in the osteosarcoma. In our study, we showed that NOVA1 expression was upregulated in osteosarcoma cell lines and tissues. The expression of NOVA1 was upregulated in 22 (22/30; 73%) osteosarcoma cases compared to that in the adjacent tissues. Overexpression of NOVA1 promoted osteosarcoma cell viability, colony formation and invasion. Furthermore, knockdown of NOVA1 suppressed osteosarcoma cell viability, colony formation and invasion. These data suggested that NOVA1 acted as an oncogene in the development of osteosarcoma.
骨肉瘤是年轻患者中最常见的骨肿瘤之一。NOVA1（神经肿瘤腹侧抗原1）是一种神经元特异性RNA结合蛋白，属于Nova家族。先前的研究表明，NOVA1在几种肿瘤的发生发展中起关键作用。我们研究的目的是探讨NOVA1在骨肉瘤中的作用。在我们的研究中，我们发现NOVA1在骨肉瘤细胞系和组织中表达上调。与相邻组织相比，22例（22/30；73%）骨肉瘤病例中NOVA1表达上调。NOVA1的过表达促进了骨肉瘤细胞的活力、集落形成和侵袭。此外，敲低NOVA1可抑制骨肉瘤细胞的活力、集落形成和侵袭。这些数据表明，NOVA1在骨肉瘤的发生发展中起癌基因的作用。
