Fu Jingke, Huo Xiaohong, Li Bowen, Zhang Wanbin
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Org Biomol Chem. 2017 Nov 29;15(46):9747-9759. doi: 10.1039/c7ob02476b.
Synergistic catalysis is gaining increasing attention due to its advantages over traditional catalytic methodologies, such as improved catalytic activity, broader substrate scope, increased selectivity and lower cost. Methodologies involving the synergistic combination of metal catalysts and organocatalysts have been intensively studied. Given the clear benefits of bimetallic catalyst systems consisting of two distinct metal catalysts, cooperative bimetallic catalysis has proved to be successful for a number of difficult asymmetric transformations. This review highlights the recent advances in bimetallic systems for catalytic asymmetric allylic substitution reactions. Strategies using a chiral metal catalyst and the cooperative effect of a second achiral metal catalyst for asymmetric transformations are discussed. Additionally, several challenging asymmetric reactions realized by employing two different chiral metal catalysts in a synergistic manner are also covered.
由于协同催化相对于传统催化方法具有诸多优势，如提高催化活性、拓宽底物范围、增强选择性和降低成本等，因此越来越受到关注。涉及金属催化剂与有机催化剂协同组合的方法已得到深入研究。鉴于由两种不同金属催化剂组成的双金属催化剂体系具有明显优势，协同双金属催化已被证明在许多困难的不对称转化反应中取得成功。本综述重点介绍了用于催化不对称烯丙基取代反应的双金属体系的最新进展。讨论了使用手性金属催化剂和第二种非手性金属催化剂的协同作用进行不对称转化的策略。此外，还涵盖了通过协同使用两种不同手性金属催化剂实现的一些具有挑战性的不对称反应。
