Lednev Vasily N, Pershin Sergey M, Sdvizhenskii Pavel A, Grishin Mikhail Ya, Fedorov Alexander N, Bukin Vladimir V, Oshurko Vadim B, Shchegolikhin Alexander N
National University of Science and Technology MISiS, Leninsky Ave. 4, Moscow, 119991, Russia.
Prokhorov General Physics Institute, Russian Academy of Science, Vavilov Str. 38, Moscow, 119991, Russia.
Anal Bioanal Chem. 2018 Jan;410(1):277-286. doi: 10.1007/s00216-017-0719-6. Epub 2017 Nov 8.
A new approach combining Raman spectrometry and laser induced breakdown spectrometry (LIBS) within a single laser event was suggested. A pulsed solid state Nd:YAG laser running in double pulse mode (two frequency-doubled sequential nanosecond laser pulses with dozens microseconds delay) was used to combine two spectrometry methods within a single instrument (Raman/LIBS spectrometer). First, a low-energy laser pulse (power density far below ablation threshold) was used for Raman measurements while a second powerful laser pulse created the plasma suitable for LIBS analysis. A short time delay between two successive pulses allows measuring LIBS and Raman spectra at different moments but within a single laser flash-lamp pumping. Principal advantages of the developed instrument include high quality Raman/LIBS spectra acquisition (due to optimal gating for Raman/LIBS independently) and absence of target thermal alteration during Raman measurements. A series of high quality Raman and LIBS spectra were acquired for inorganic salts (gypsum, anhydrite) as well as for pharmaceutical samples (acetylsalicylic acid). To the best of our knowledge, the quantitative analysis feasibility by combined Raman/LIBS instrument was demonstrated for the first time by calibration curves construction for acetylsalicylic acid (Raman) and copper (LIBS) in gypsum matrix. Combining ablation pulses and Raman measurements (LIBS/Raman measurements) within a single instrument makes it an efficient tool for identification of samples hidden by non-transparent covering or performing depth profiling analysis including remote sensing. Graphical abstract Combining Raman and laser induced breakdown spectroscopy by double pulse lasing.
提出了一种在单个激光事件中结合拉曼光谱和激光诱导击穿光谱（LIBS）的新方法。使用运行在双脉冲模式（两个频率加倍的连续纳秒激光脉冲，延迟几十微秒）的脉冲固态Nd:YAG激光器，在单一仪器（拉曼/LIBS光谱仪）中结合两种光谱方法。首先，低能量激光脉冲（功率密度远低于烧蚀阈值）用于拉曼测量，而第二个强激光脉冲产生适合LIBS分析的等离子体。两个连续脉冲之间的短时间延迟允许在不同时刻但在单个激光闪光灯泵浦内测量LIBS和拉曼光谱。所开发仪器的主要优点包括高质量的拉曼/LIBS光谱采集（由于分别对拉曼/LIBS进行了最佳选通）以及在拉曼测量期间不存在目标热变化。获得了一系列无机盐（石膏、硬石膏）以及药物样品（乙酰水杨酸）的高质量拉曼和LIBS光谱。据我们所知，通过构建石膏基质中乙酰水杨酸（拉曼）和铜（LIBS）的校准曲线，首次证明了联合拉曼/LIBS仪器进行定量分析的可行性。在单一仪器中结合烧蚀脉冲和拉曼测量（LIBS/拉曼测量）使其成为识别被不透明覆盖物隐藏的样品或进行包括遥感在内的深度剖析分析的有效工具。图形摘要 通过双脉冲激光结合拉曼光谱和激光诱导击穿光谱。
