实验性失血和复合性创伤性脑损伤后创伤期接受Mexicor治疗期间红细胞的功能和生化参数
Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury.
作者信息
Deryugina A V, Shumilova A V, Filippenko E S, Galkina Ya V, Simutis I S, Boyarinov G A
机构信息
Department of Biochemistry and Physiology, N. I. Lobachevsky National Research Nizhny Novgorod State University, Nizhny Novgorod, Russia.
Department of Anesthesiology and Reanimatology, Municipal Clinical Hospital No. 40, Nizhny Novgorod, Russia.
出版信息
Bull Exp Biol Med. 2017 Nov;164(1):26-29. doi: 10.1007/s10517-017-3918-4. Epub 2017 Nov 9.
Mexicor treatment (8 mg/kg body weight per day) during the posttraumatic period after concomitant traumatic brain injury and acute blood loss in rats increased electrophoretic mobility and concentration of 2,3-diphosphoglycerate, and reduced malondialdehyde content in erythrocytes. These changes improved hemodynamics and oxygen-transporting function of the blood. The most pronounced effects of Mexicor were observed at the early stages of posttraumatic period.
在大鼠发生创伤性脑损伤并伴有急性失血后的创伤后时期，给予Mexicor治疗（每天8毫克/千克体重）可提高红细胞中2,3-二磷酸甘油酸的电泳迁移率和浓度，并降低丙二醛含量。这些变化改善了血液的血流动力学和氧运输功能。Mexicor的最显著效果在创伤后时期的早期阶段观察到。
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