蛋白酪氨酸磷酸酶非受体型22基因1858位C/T多态性在埃及青少年特发性关节炎患者中的作用

Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients.

作者信息

Soliman Yasser A, Hashaad Nashwa I, Emam Sherin M, Mohamed Rehab R

机构信息

Department of Rheumatology & Rehabilitation & Physical Medicine, Faculty of Medicine, Benha University, Benha, Egypt.

Department of Microbiology & Immunology, Faculty of Medicine, Benha University, Benha, Egypt.

出版信息

Egypt J Immunol. 2017 Jan;24(1):95-104.

PMID:29120582

Abstract

Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0.021). Different PTPN genotypes were studied in relation to patient's age, sex and relevant laboratory data. It was concluded that PTPN22 polymorphism is different in JIA patients than healthy controls. T allele is associated only in cases with JIA and it may be considered as risk allele for certain JIA subtypes.

摘要

幼年特发性关节炎（JIA）是儿童期最常见的慢性关节病，是一组多样化的慢性关节炎疾病。蛋白酪氨酸磷酸酶N22（PTPN22）基因对T细胞和B细胞均具有调节活性。本研究旨在探讨JIA患者中PTPN基因多态性。该研究纳入了60例JIA患儿，并选取40例年龄和性别匹配的健康儿童作为对照。对患者组和对照组进行PTPN基因多态性分析。我们的研究结果表明，JIA患者与对照组之间PTPN22多态性存在显著差异（P = 0.021）。针对患者的年龄、性别及相关实验室数据，对不同的PTPN基因型进行了研究。得出的结论是，JIA患者的PTPN22多态性与健康对照不同。T等位基因仅在JIA患者中出现，可能被视为某些JIA亚型的风险等位基因。