Benedetto C, Massobrio M, Bertini E, Abbondanza M, Enrieu N, Tetta C
Istituto di Ginecologia e Ostetricia dell'Università degli Studi di Torino, Italy.
Am J Obstet Gynecol. 1989 Jan;160(1):100-4. doi: 10.1016/0002-9378(89)90097-5.
We determined in normal nonpregnant (group 1) women, normal pregnant (group 2) women, and patients with preeclampsia (group 3) the serum inhibition of platelet-activating factor activity, the presence of detectable amounts of platelet-activating factor in the blood, and platelet responsiveness in vitro to platelet-activating factor, and to other agonists (adenosine diphosphate, collagen, and ristocetin), and prostacyclin (prostaglandin I2). In patients with preeclampsia (group 3) the serum inhibition of platelet-activating factor activity was significantly lower than that in groups 1 and 2. However, no detectable amounts of platelet-activating factor were observed. The mean values of platelet aggregation induced by platelet-activating factor, adenosine diphosphate, collagen and ristocetin, and the prostaglandin I2-inhibitory concentration of 50% which is inversely correlated with platelet sensitivity to prostaglandin I2, were not significantly different between groups 2 and 3. It is suggested that in preeclampsia the defect in serum inhibitory potential of platelet-activating factor--induced platelet aggregation may contribute to the disturbance in the homeostatic balance between proaggregant and antiaggregant substances.
我们测定了正常未孕女性（第1组）、正常孕妇（第2组）和先兆子痫患者（第3组）血清对血小板活化因子活性的抑制作用、血液中可检测到的血小板活化因子的存在情况、血小板在体外对血小板活化因子以及其他激动剂（二磷酸腺苷、胶原和瑞斯托菌素）和前列环素（前列腺素I2）的反应性。在先兆子痫患者（第3组）中，血清对血小板活化因子活性的抑制作用明显低于第1组和第2组。然而，未观察到可检测到的血小板活化因子量。第2组和第3组之间，由血小板活化因子、二磷酸腺苷、胶原和瑞斯托菌素诱导的血小板聚集平均值以及与血小板对前列腺素I2敏感性呈负相关的50%前列腺素I2抑制浓度，差异均无统计学意义。提示在先兆子痫中，血清对血小板活化因子诱导的血小板聚集的抑制潜能缺陷可能导致促聚集和抗聚集物质之间稳态平衡的紊乱。
