Department of Internal Medicine, ASST Spedali Civili di Brescia.
Department of Clinical and Experimental Sciences.
J Hypertens. 2018 Mar;36(3):580-586. doi: 10.1097/HJH.0000000000001595.
Wall-to-lumen ratio of retinal arterioles (W/L ratio) might serve as an in-vivo parameter of microvascular damage. No study has investigated the relationship between carotid stiffness and W/L ratio of retinal arteries. Therefore, the aim of the current study was to assess the correlation between local carotid stiffness, as assessed by echotracking technique, and W/L ratio of retinal arterioles, as assessed by noninvasive flowmetry in normotensive patients and in patients with primary hypertension.
Two hundred and twenty-seven patients underwent renal arteries W/L ratio and local carotid-pulse wave velocity (carotid PWV) measurement. One hundred and fifteen patients had a diagnosis of primary hypertension, whereas 112 were normotensive patients.
W/L ratio and carotid PWV were both related with clinic SBP (r = 0.17, P < 0.05; r = 0.50, P < 0.001), clinic pulse pressure (r = 0.22, P < 0.001; r = 0.55, P < 0.001), carotid SBP (r = 0.18, P < 0.05; r = 0.51, P < 0.001) and carotid pulse pressure (r = 0.24, P < 0.001; r = 0.56, P < 0.001). W/L ratio was correlated with carotid PWV (r = 0.18, P < 0.005). At multivariate analysis, carotid PWV remained independently associated with W/L ratio.
In hypertensive and normotensive patients, carotid stiffness is significantly correlated with W/L ratio of retinal arteries, independently of possible confounders.
视网膜小动脉的壁腔比（W/L 比）可能作为微血管损伤的体内参数。尚无研究调查颈动脉僵硬度与视网膜动脉 W/L 比之间的关系。因此，本研究旨在评估在血压正常的患者和原发性高血压患者中，通过超声跟踪技术评估的局部颈动脉僵硬度与无创血流测量的视网膜小动脉 W/L 比之间的相关性。
227 例患者接受了肾动脉 W/L 比和局部颈动脉脉搏波速度（颈动脉 PWV）测量。115 例患者诊断为原发性高血压，112 例为血压正常的患者。
W/L 比和颈动脉 PWV 均与诊室收缩压（r=0.17，P<0.05；r=0.50，P<0.001）、诊室脉压（r=0.22，P<0.001；r=0.55，P<0.001）、颈动脉收缩压（r=0.18，P<0.05；r=0.51，P<0.001）和颈动脉脉压（r=0.24，P<0.001；r=0.56，P<0.001）相关。W/L 比与颈动脉 PWV 相关（r=0.18，P<0.005）。多元分析显示，颈动脉 PWV 与 W/L 比独立相关。
在高血压和血压正常的患者中，颈动脉僵硬度与视网膜小动脉的 W/L 比显著相关，独立于可能的混杂因素。
