Shin Hee-Soon, Eom Ji-Eun, Shin Dong-Uk, Yeon Sung-Hum, Lim Seong-Il, Lee So-Young
Research Group of Gut Microbiome, Korea Food Research Institute, Wanju 55365, Republic of Korea.
University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
J Microbiol Biotechnol. 2018 Jan 28;28(1):65-76. doi: 10.4014/jmb.1708.08051.
Although there has been a steady increase in the prevalence of food allergies worldwide in recent decades, no effective therapeutic strategies have been developed. Modulation of the gut microbiota composition and/or function through probiotics has been highlighted as a promising target for protection against food allergies. In this study, we aimed to investigate the allergy-reducing effects of a probiotic mixture (P5: KF140, KF159, KF340, 698, and 26N) in mice with ovalbumin (OVA)-induced food allergy. Administration of P5 significantly suppressed the oral OVA challenge-induced anaphylactic response and rectal temperature decline, and reduced diarrhea symptoms. Moreover, P5 also significantly inhibited the secretion of IgE, Th2 cytokines (interleukin (IL)-4, IL-5, IL-10, and IL-13), and Th17 cytokines (IL-17), which were increased in mice with OVA-induced food allergy, and induced generation of CD4+Foxp3+ regulatory T cells. These results revealed that P5 may have applications as a preventive agent against food allergy.
尽管近几十年来全球食物过敏的患病率一直在稳步上升，但尚未开发出有效的治疗策略。通过益生菌调节肠道微生物群的组成和/或功能已被视为预防食物过敏的一个有前景的靶点。在本研究中，我们旨在研究一种益生菌混合物（P5：KF140、KF159、KF340、698和26N）对卵清蛋白（OVA）诱导的食物过敏小鼠的抗过敏作用。给予P5可显著抑制口服OVA激发诱导的过敏反应和直肠温度下降，并减轻腹泻症状。此外，P5还显著抑制了OVA诱导的食物过敏小鼠体内升高的IgE、Th2细胞因子（白细胞介素（IL）-4、IL-5、IL-10和IL-13）以及Th17细胞因子（IL-17）的分泌，并诱导了CD4+Foxp3+调节性T细胞的生成。这些结果表明，P5可能作为一种预防食物过敏的药物具有应用价值。
