Jordan D A, Breslow M J, Kubos K L, Traystman R J
Department of Anesthesiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Am J Physiol. 1989 Jan;256(1 Pt 2):H233-9. doi: 10.1152/ajpheart.1989.256.1.H233.
The present study evaluates possible effects of adrenal catecholamines, released by splanchnic nerve stimulation, on adrenal medullary blood flow (MQ) and adrenal catecholamine secretion (CS). Twelve pentobarbital-anesthetized mongrel dogs were subjected to three identical splanchnic nerve stimulations (5 V, 20 Hz, for 3 min) at 30-min intervals, and MQ (radiolabeled microsphere technique) and CS (high-performance liquid chromatography) were measured before and during each nerve stimulation. Animals were assigned to one of three groups and administered either saline, pindolol (1 and 4 mg/kg), or prazosin (1 and 4 mg/kg) before the second and third nerve stimulation, respectively. In the saline control group, each nerve stimulation resulted in similar increases in MQ and CS. Pindolol attenuated nerve stimulation-induced increases in MQ and CS by 50%, but had no effect on medullary catecholamine concentration. Prazosin augmented nerve stimulation-induced MQ, CS, and medullary catecholamine concentration by 35%. These data suggest that adrenal adrenergic receptors modulate elicited CS and mediate changes in adrenal medullary vascular tone.
本研究评估了内脏神经刺激释放的肾上腺儿茶酚胺对肾上腺髓质血流量（MQ）和肾上腺儿茶酚胺分泌（CS）的可能影响。12只戊巴比妥麻醉的杂种狗每隔30分钟接受三次相同的内脏神经刺激（5伏，20赫兹，持续3分钟），并在每次神经刺激之前和期间测量MQ（放射性微球技术）和CS（高效液相色谱法）。将动物分为三组之一，并分别在第二次和第三次神经刺激之前给予生理盐水、吲哚洛尔（1和4毫克/千克）或哌唑嗪（1和4毫克/千克）。在生理盐水对照组中，每次神经刺激均导致MQ和CS出现类似的增加。吲哚洛尔使神经刺激引起的MQ和CS增加减弱了50%，但对髓质儿茶酚胺浓度没有影响。哌唑嗪使神经刺激引起的MQ、CS和髓质儿茶酚胺浓度增加了35%。这些数据表明，肾上腺肾上腺素能受体调节诱发的CS，并介导肾上腺髓质血管张力的变化。
