[The pentoxifylline, a corticosteroid sparing in the treatment of sarcoidosis: A case report].
作者信息
Diallo B D, Diot B, Flament T, Plantier L, Diot P, Sow O Y, Marchand-Adam S
机构信息
Service de pneumologie et explorations fonctionnelles respiratoires, CHU de Tours, 37032 Tours, France; Inserm U-1100/EA-6305, centre d'études des pathologies respiratoires, faculté de médicine François-Rabelais, 37032 Tours, France; Service de pneumologie, hôpital Ignace-Deen, Conakry, Guinée.
Service de pneumologie et explorations fonctionnelles respiratoires, CHU de Tours, 37032 Tours, France.
出版信息
Rev Pneumol Clin. 2018 Feb;74(1):48-51. doi: 10.1016/j.pneumo.2017.08.014. Epub 2017 Nov 6.
INTRODUCTION
The pentoxifylline seems to have some effects on immune cells by inhibiting tumor necrosis factor alpha (TNFα). Its role as a sparing corticosteroids in the treatment of sarcoidosis remains to be defined.
CLINICAL CASE
We present the case of a patient with sarcoidosis corticodependent despite the use of azathioprine. It was finally improved clinically, functionally and by a thoracic computed tomography with addition of pentoxifylline.
CONCLUSION
When the tolerance of the pentoxifylline is good and there is not a bleeding risk, the benefit-risk in the long term might be interesting in some patients with sarcoidosis corticodependent.
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