Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081 Ulm, Germany.
Ulm Peptide Pharmaceuticals, Ulm University, Albert-Einstein-Allee 47, 89081 Ulm, Germany; Core Facility Functional Peptidomics, Ulm University Medical Center, Albert-Einstein-Allee 47, 89081 Ulm, Germany.
Bioorg Med Chem. 2018 Jun 1;26(10):2719-2726. doi: 10.1016/j.bmc.2017.10.038. Epub 2017 Oct 31.
Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds.
传染病和癌症是主要的死亡原因，对公共卫生构成重大挑战。人类肽组包含数以百万计的化合物，具有巨大的结构和功能多样性，是发现具有抗菌和/或抗癌活性的内源性药物的绝佳来源。在这里，我们讨论了如何通过从人体体液和组织中生成肽文库并逐步纯化生物活性化合物，利用人类肽组来开发新型抗菌和抗癌药物。
