Stefkovich Megan L, Arao Yukitomo, Hamilton Katherine J, Korach Kenneth S
Receptor Biology Section, Reproductive and Developmental Biology Laboratory, National Institutes of Health, NIEHS, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA.
Receptor Biology Section, Reproductive and Developmental Biology Laboratory, National Institutes of Health, NIEHS, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA.
Steroids. 2018 May;133:34-37. doi: 10.1016/j.steroids.2017.11.001. Epub 2017 Nov 6.
Non-genomic effects of estrogen receptor α (ERα) signaling have been described for decades. However, the mechanisms and physiological processes resulting solely from non-genomic signaling are poorly understood. Challenges in studying these effects arise from the strongly nucleophilic tendencies of estrogen receptor, and many approaches to excluding ERα from the nucleus have been explored over the years. In this review, we discuss past strategies for studying ERα's non-genomic action and current models, specifically H2NES ERα, first described by Burns et al. (2011). In vitro and preliminary in vivo data from H2NES ERα and H2NES mice suggest a promising avenue for pinpointing specific non-genomic ERα action.
几十年来，雌激素受体α（ERα）信号的非基因组效应已被描述。然而，仅由非基因组信号产生的机制和生理过程却知之甚少。研究这些效应的挑战源于雌激素受体强烈的亲核倾向，多年来人们探索了许多将ERα排除在细胞核外的方法。在这篇综述中，我们讨论了过去研究ERα非基因组作用的策略和当前的模型，特别是Burns等人（2011年）首次描述的H2NES ERα。来自H2NES ERα和H2NES小鼠的体外和初步体内数据为确定特定的非基因组ERα作用指明了一条有前景的途径。
