Department of Neurology, Shanghai No. 5 hospital, Fudan University, Shanghai, China.
Department of Neurology, Shanghai No. 5 hospital, Fudan University, Shanghai, China.
Brain Res. 2018 Jan 15;1679:1-9. doi: 10.1016/j.brainres.2017.11.003. Epub 2017 Nov 6.
Although it has been proved that remote limb preconditioning (RPC) can exert neurological protection effects after ischemic cerebral stroke (ICS), the underlying mechanisms of RPC still need to be elucidated for its better transformation to clinical application. Lipocalin-2 (LCN2) was upregulated after cerebral ischemia and mediated reperfusion injury in the models of ischemic stroke. So here, we investigated that whether RPC could downregulate the levels of LCN2 protein and its receptor resulting from cerebral ischemia reperfusion (I/R) injury. The results showed that RPC could decrease the expression of LCN2 protein, but having no obvious effects on its receptor except the time point of 72 h after cerebral ischemia. Furthermore, we observed the downregulation of Bim after RPC in the course of ICS.
虽然已经证明远程肢体预处理（RPC）可以在缺血性脑卒中（ICS）后发挥神经保护作用，但为了更好地将其转化为临床应用，仍需要阐明其潜在机制。脂联素 2（LCN2）在脑缺血后上调，并在缺血性脑卒中模型中介导再灌注损伤。因此，在这里，我们研究了 RPC 是否可以下调脑缺血再灌注（I/R）损伤引起的 LCN2 蛋白及其受体的水平。结果表明，RPC 可以降低 LCN2 蛋白的表达，但对其受体除脑缺血后 72 小时的时间点外，没有明显影响。此外，我们在 ICS 过程中观察到 RPC 后 Bim 的下调。
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