MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Department of Population Health Sciences, Bristol Medical School, Bristol, UK.
J Epidemiol Community Health. 2018 Jan;72(1):34-40. doi: 10.1136/jech-2017-209488. Epub 2017 Nov 9.
Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan.
We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children. We used confirmatory factor analysis to characterise lack of care, maladaptive family functioning, non-sexual abuse, overprotective parenting, parental mental illness and sexual abuse. These specific components of childhood psychosocial adversity were combined into a total psychosocial adversity score using a second-order factor analysis. We used structural equation models to simultaneously conduct the factor analysis and estimate the association with the continuous outcomes of interest.
Total childhood psychosocial adversity was not associated with age at menarche, age at menopause or length of reproductive lifespan. When we examined the separate psychosocial adversity constructs, sexual abuse was inversely associated with age at menarche, with a mean difference of -0.17 (95% CI -0.23 to -0.12) years per SD higher factor score, and with age at menopause, with a mean difference of -0.17 (95% CI -0.52 to 0.18) per SD higher factor score.
Childhood sexual abuse was associated with lower age at menarche and menopause, but the latter needs to be confirmed in larger samples.
之前有关儿童心理社会逆境和初潮年龄的研究大多评估了单一或少数几种逆境测量指标，因此无法量化总的心理社会逆境。目前关于儿童心理社会逆境与绝经年龄和生殖寿命的关系知之甚少。
我们在参与阿冯纵向父母与子女研究的母亲中，研究了儿童心理社会逆境的总成分和特定成分与初潮年龄（n=8984）、绝经年龄（n=945）和生殖寿命（n=841）的关系。我们使用验证性因子分析来描述缺乏关爱、适应不良的家庭功能、非性虐待、过度保护的养育方式、父母的精神疾病和性虐待。这些儿童心理社会逆境的特定成分使用二阶因子分析组合成一个总的心理社会逆境评分。我们使用结构方程模型同时进行因子分析和估计与感兴趣的连续结果的关联。
总的儿童心理社会逆境与初潮年龄、绝经年龄或生殖寿命无关。当我们检查单独的心理社会逆境结构时，性虐待与初潮年龄呈负相关，平均差异为 -0.17（95%CI -0.23 至 -0.12）岁/标准差更高的因子得分，与绝经年龄呈负相关，平均差异为 -0.17（95%CI -0.52 至 0.18）岁/标准差更高的因子得分。
儿童期性虐待与初潮年龄和绝经年龄较低有关，但后者需要在更大的样本中得到证实。
Zotero 插件