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用于热化疗联合治疗的多功能金纳米棒与多西他赛包裹脂质体

Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy.

作者信息

Hua Haiying, Zhang Nan, Liu Dan, Song Lili, Liu Tuanbing, Li Shasha, Zhao Yongxing

机构信息

Academy of Medical and Pharmaceutical Sciences.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University.

出版信息

Int J Nanomedicine. 2017 Oct 25;12:7869-7884. doi: 10.2147/IJN.S143977. eCollection 2017.

DOI:10.2147/IJN.S143977
PMID:29123399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5661837/
Abstract

Personalized and precise nanomedicines are highly demanded for today's medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice. Results showed that GNRs/DocL-R possessed a diameter approximately 163.15±1.83 nm and a zeta potential approximately -32.8±2.16 mV. GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo. Therefore, the multifunctional GNRs/DocL-R was a potential cancer treatment via combined chemo- and thermotherapy.

摘要

当今的医学需求对个性化和精准的纳米药物有很高的要求。脂质体是构建多功能药物递送系统的理想候选者。在本研究中，使用脂质体来改善多西他赛（Doc）的临床问题，多西他赛是一种用于前列腺癌（PC）的强效抗有丝分裂化疗药物。将低密度脂蛋白受体（LDLR）结合肽RLT和聚乙二醇（PEG）偶联到脂质体上，并且还将金纳米棒（GNRs）掺入脂质体中。在PC-3细胞和PC-3荷瘤裸鼠中对GNRs/Doc-脂质体-RLT（GNRs/DocL-R）进行了测试。结果表明，GNRs/DocL-R的直径约为163.15±1.83nm，zeta电位约为-32.8±2.16mV。GNRs/DocL-R显示出增强的细胞内摄取、在植入肿瘤区域的积累增加以及在体外和体内的最高肿瘤抑制作用。因此，多功能的GNRs/DocL-R通过化学疗法和热疗法的联合是一种潜在的癌症治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/69d9b3221902/ijn-12-7869Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/72300c7aa111/ijn-12-7869Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/f16c19dd66ad/ijn-12-7869Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/2eccbb577128/ijn-12-7869Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/ef744be90a41/ijn-12-7869Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/c310b38504eb/ijn-12-7869Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/dcabb7427a01/ijn-12-7869Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/69d9b3221902/ijn-12-7869Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/72300c7aa111/ijn-12-7869Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/f16c19dd66ad/ijn-12-7869Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/2eccbb577128/ijn-12-7869Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/ef744be90a41/ijn-12-7869Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/c310b38504eb/ijn-12-7869Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/dcabb7427a01/ijn-12-7869Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98a/5661837/69d9b3221902/ijn-12-7869Fig7.jpg

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