Impaired Rab7 and Dynamin2 Block Fat Turnover by Autophagy in Alcoholic Fatty Livers.
作者信息
Li Yuan, Ding Wen-Xing
机构信息
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
出版信息
Hepatol Commun. 2017 Aug;1(6):473-476. doi: 10.1002/hep4.1067. Epub 2017 Aug 2.
Abstract
摘要
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本文引用的文献
1
Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7.
Hepatol Commun. 2017 Mar 10;1(2):140-152. doi: 10.1002/hep4.1021. eCollection 2017 Apr.
2
Ethanol-induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity.
Hepatol Commun. 2017 Aug;1(6):501-512. doi: 10.1002/hep4.1063. Epub 2017 Jul 10.
3
β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure.
J Biol Chem. 2017 Jul 14;292(28):11815-11828. doi: 10.1074/jbc.M117.777748. Epub 2017 May 17.
4
Recent progress in autophagic lysosome reformation.
Traffic. 2017 Jun;18(6):358-361. doi: 10.1111/tra.12484. Epub 2017 May 5.
5
A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.
Sci Adv. 2016 Dec 16;2(12):e1601470. doi: 10.1126/sciadv.1601470. eCollection 2016 Dec.
6
Hepatic lipid droplet biology: Getting to the root of fatty liver.
Hepatology. 2015 Sep;62(3):964-7. doi: 10.1002/hep.27839. Epub 2015 May 9.
7
The small GTPase Rab7 as a central regulator of hepatocellular lipophagy.
Hepatology. 2015 Jun;61(6):1896-907. doi: 10.1002/hep.27667. Epub 2015 Apr 23.
8
New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.
World J Gastroenterol. 2014 Sep 28;20(36):12908-33. doi: 10.3748/wjg.v20.i36.12908.
9
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.
J Cell Biol. 2013 Oct 28;203(2):315-26. doi: 10.1083/jcb.201306140. Epub 2013 Oct 21.
10
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine.
Nat Med. 2013 Jan;19(1):83-92. doi: 10.1038/nm.3014. Epub 2012 Dec 2.
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