Cerrahpaşa School of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.
Neurol Sci. 2018 Feb;39(2):313-319. doi: 10.1007/s10072-017-3185-1. Epub 2017 Nov 9.
We hypothesized the filtering of sensory input from face and hand at brainstem may reorganize in hemifacial spasm (HFS) and postparalytic facial syndrome (PFS). Thus, we examined the prepulse inhibition of blink reflex (BR-PPI) in HFS and PFS. We included 12 healthy subjects, 13 patients with HFS, and 11 patients with PFS. Baseline BR, BR recovery at interstimulus interval (ISI) of 300 ms and BR-PPI at ISI of 100 ms were performed on the right sides of healthy subjects and on both sides of patients. Within-subject analysis showed baseline BR and BR-PPI were similar between asymptomatic and symptomatic sides of patients with HFS whereas BR recovery was higher on the symptomatic side. In the PFS group, latency of R2 during baseline BR recording was longer (p = 0.022) and R2 amplitude (p = 0.046) was reduced on the symptomatic side compared to asymptomatic side. Reduction of R2 area in BR-PPI recordings was also the lowest in HFS compared to other two groups (p = 0.000); however, it was also lower in patients with PFS compared to healthy subjects (p = 0.018). BR-PPI was decreased on both sides of patients. The mean R2 recovery was higher on both sides of patients with HFS and PFS (p = 0.007). Filtering of facial sensory input is decreased probably to monitor and to correct the sequence of facial movements in these disorders.
我们假设脑干对面部和手部感觉输入的过滤可能在半面痉挛（HFS）和面瘫后综合征（PFS）中重新组织。因此，我们研究了 HFS 和 PFS 中的眨眼反射（BR）的预激抑制（BR-PPI）。我们纳入了 12 名健康受试者、13 名 HFS 患者和 11 名 PFS 患者。在健康受试者的右侧和患者的两侧进行了基线 BR、ISI 为 300ms 时的 BR 恢复和 ISI 为 100ms 时的 BR-PPI。在患者中，无症状和有症状侧的基线 BR 和 BR-PPI 相似，而有症状侧的 BR 恢复更高。在 PFS 组中，基线 BR 记录时 R2 的潜伏期较长（p=0.022），R2 振幅较低（p=0.046）与无症状侧相比。BR-PPI 记录中 R2 面积的减少在 HFS 中也低于其他两组（p=0.000）；然而，与健康受试者相比，PFS 患者的减少也较低（p=0.018）。BR-PPI 在患者的两侧均减少。HFS 和 PFS 患者的两侧 R2 恢复均较高（p=0.007）。这些疾病中对面部感觉输入的过滤减少可能是为了监测和纠正面部运动的顺序。
