Cattaneo Luigi, Chierici Elisabetta, Pavesi Giovanni
Dipartimento di Neuroscienze, Sezione di Neurologia, Università degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy.
Clin Neurophysiol. 2005 Oct;116(10):2348-53. doi: 10.1016/j.clinph.2005.06.018.
We describe the case of a woman with Bell's Palsy-induced blepharospasm (BPIB) of the right eye that appeared simultaneously with a complete left facial nerve palsy. The involuntary spasm was relieved by passive lowering of the upper eyelid on the paretic side.
The recovery curve of the blink reflex was evaluated on the non-paretic side in baseline conditions, after subcutaneous apomorphine and placebo administration and 8 months later, at recovery from the palsy.
We found increased recovery of the test-R2 responses at short interstimulus intervals at baseline, which was normalised by apomorphine but not by placebo. At recovery the blink reflex R2 recovery curve returned to normal.
This report demonstrates for the first time a response of BPIB to a dopamine agonist.
Our findings are in agreement with an animal model of blepharospasm that suggests a combined role of weakness of the orbicularis oculi muscle and a dysfunction of the dopaminergic system in the pathogenesis of this disorder.
我们描述了一名患有右眼贝尔麻痹诱发睑痉挛（BPIB）的女性病例，该症状与左侧完全性面神经麻痹同时出现。通过被动降低患侧上眼睑可缓解不自主痉挛。
在基线条件下、皮下注射阿扑吗啡和安慰剂后以及8个月后（面神经麻痹恢复时），对非患侧的瞬目反射恢复曲线进行评估。
我们发现基线时短刺激间隔下测试R2反应的恢复增加，阿扑吗啡可使其恢复正常，但安慰剂无此作用。恢复时，瞬目反射R2恢复曲线恢复正常。
本报告首次证明了BPIB对多巴胺激动剂有反应。
我们的发现与睑痉挛动物模型一致，该模型表明眼轮匝肌无力和多巴胺能系统功能障碍在这种疾病的发病机制中起联合作用。
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