Laher I, Bevan J A
Department of Pharmacology, University of Vermont, Burlington 05405.
Biochem Biophys Res Commun. 1989 Jan 16;158(1):58-62. doi: 10.1016/s0006-291x(89)80176-7.
The effects of protein kinase C inhibition by staurosporine was studied on Ca-dependent tone of the rabbit facial vein. Tone was produced either by stretch or by readmission of Ca2+ in a non-depolarizing Ca2+-free salt solution. Stretch-induced tone was inhibited by staurosporine. When tissues were incubated in a Ca2+-free solution, staurosporine (50 nM) inhibited the contractile responses produced by readmission of Ca2+. These observations suggest that maintenance of stretch-induced extracellular Ca2+-dependent tone may be regulated by protein kinase C.
