a Centro Asistencial Universitario, Universidad Nacional de San Martín , Buenos Aires , Argentina.
b Residencia de Investigación en Salud , Gobierno de la Ciudad Autónoma de Buenos Aires, CABA , Argentina.
Expert Rev Neurother. 2018 Jan;18(1):65-82. doi: 10.1080/14737175.2018.1400910. Epub 2017 Nov 10.
Stroke is one of the most prevalent neurological diseases worldwide, especially among the elderly population. There are various mechanisms that enhance motor recovery after a stroke. In clinical practice, we have the opportunity to enhance plasticity by designing specific rehabilitation programs. Areas covered: There are a variety of drugs commonly administered to people after the acute phase of a stroke. These drugs may modify motor performance. Herein reviewed is the evidence concerning motor enhancement or decline in stroke patients, produced by drugs commonly used in rehabilitation settings. An extensive review of animal and human studies is performed. Expert commentary: Many of the clinical trials carried out were underpowered. Modest evidence supports the claim that there are agents that can affect motor rehabilitation after a stroke. Amphetamine-like agents, serotonin reuptake inhibitors, and levodopa might improve motor outcomes, while antipsychotics, some antiepileptic drugs, and GABAmimetic drugs could impair the recovery process. To draw definite recommendations, more comprehensive knowledge about the efficacy, long-term effects, and safety of these drugs is required. There are also other interesting molecules that open a promising field for basic and clinical research, in the search for new therapeutic options.
中风是全球最常见的神经疾病之一，尤其是在老年人群中。有多种机制可以增强中风后的运动功能恢复。在临床实践中，我们有机会通过设计特定的康复方案来增强可塑性。
中风后，人们通常会使用各种药物。这些药物可能会改变运动表现。本文综述了在康复环境中常用药物对中风患者运动功能增强或下降的证据。对动物和人类研究进行了广泛的回顾。
许多进行的临床试验都没有足够的效力。有适度的证据支持这样一种说法，即有一些药物可以影响中风后的运动康复。安非他命样药物、5-羟色胺再摄取抑制剂和左旋多巴可能改善运动结果，而抗精神病药、一些抗癫痫药和 GABA 拟似物可能会损害恢复过程。为了得出明确的建议，需要更全面地了解这些药物的疗效、长期效果和安全性。还有其他一些有趣的分子为基础和临床研究开辟了一个有前途的领域，以寻找新的治疗选择。
