Karakas Yusuf, Lacin Sahin, Yalcin Suayib
a Department of Medical Oncology , Cancer Institute, Hacettepe University , Ankara , Turkey.
Expert Rev Anticancer Ther. 2018 Jan;18(1):51-62. doi: 10.1080/14737140.2018.1403319. Epub 2017 Nov 13.
Pancreatic cancer (PC) demonstrates very poor prognosis and its incidence continues to increase, despite developments in chemotherapy, radiotherapy, and targeted therapies. Surgical resection is currently the only curative approach for PC. The role of radiotherapy in adjuvant and locally advanced PC continues to be increasingly controversial. This review article aims to explore the current knowledge of pancreatic adenocarcinoma, focusing on diagnosis, treatment strategies, and the best supportive care. Areas covered: The current literature on pancreatic adenocarcinoma treatment modalities has been summarized, with a focus on clinical trials and reviews. New treatment strategies and their impact on clinical practice have also been discussed. Expert commentary: Despite many therapeutic developments, only modest improvements in survival rates have been achieved. There is an essential need to increase survival by developing more innovative treatment approaches for patients with PC.
尽管在化疗、放疗和靶向治疗方面取得了进展，但胰腺癌（PC）的预后仍然很差，其发病率持续上升。手术切除是目前治疗胰腺癌的唯一治愈方法。放疗在辅助治疗和局部晚期胰腺癌中的作用一直存在越来越多的争议。这篇综述文章旨在探讨胰腺腺癌的现有知识，重点关注诊断、治疗策略和最佳支持治疗。涵盖领域：总结了关于胰腺腺癌治疗方式的当前文献，重点是临床试验和综述。还讨论了新的治疗策略及其对临床实践的影响。专家评论：尽管有许多治疗进展，但生存率仅取得了适度提高。迫切需要通过为胰腺癌患者开发更具创新性的治疗方法来提高生存率。
