一种可能预防定植和传播的新型百日咳疫苗。
A New Whooping Cough Vaccine That May Prevent Colonization and Transmission.
作者信息
Brennan Michael J
机构信息
Aeras, 1405 Research Blvd., Rockville, MD 20850, USA.
Iliad Biotechnologies, 230 East 15th Street, Suite 1-A, New York, NY 10003, USA.
出版信息
Vaccines (Basel). 2017 Nov 10;5(4):43. doi: 10.3390/vaccines5040043.
Abstract
This article is a Letter to the Editor. The major purpose of this Letter is to highlight the development of a new genetically altered whooping cough vaccine. Recently a baboon model has been used to show that this next generation pertussis vaccine can prevent colonization, as well as disease, and elicit antibodies against major pertussis antigens. Two phase I clinical trials have been performed, showing that this new vaccine is safe in humans, and a phase II trial will be performed in the US in 2018.
摘要
本文是一封致编辑的信。这封信的主要目的是强调一种新型基因改造百日咳疫苗的进展。最近，一种狒狒模型已被用于表明这种下一代百日咳疫苗可以预防定植以及疾病，并引发针对主要百日咳抗原的抗体。已经进行了两项I期临床试验，表明这种新疫苗在人体中是安全的，并且将于2018年在美国进行II期试验。
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2
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Asymptomatic transmission and the resurgence of Bordetella pertussis.百日咳博德特氏菌的无症状传播及再度流行
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