Vascular Biology and Stem Cell Research Laboratory, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Int J Mol Sci. 2017 Nov 10;18(11):2383. doi: 10.3390/ijms18112383.
(Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules. So, both transcriptional factors KLF2 and NF-κB are being associated with the similar cellular functions and their maintenance. It was shown that KLF2 regulates most of the NF-κB-mediated activities. In this review, we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-κB.
（Kruppel 样因子 2）是锌指转录因子家族的成员，对胚胎肺发育、内皮细胞功能以及 T 细胞和单核细胞的静止状态的维持至关重要。它在幼稚 T 细胞和单核细胞中表达，但在激活和分化过程中表达水平降低。KLF2 在各种炎症性疾病及其发病机制中也发挥着关键的调节作用。核因子-κB（NF-κB）是炎症的重要诱导因子，炎症是通过几种促炎细胞因子、趋化因子和黏附分子的转录来介导的。因此，转录因子 KLF2 和 NF-κB 与相似的细胞功能及其维持有关。已经表明，KLF2 调节大多数 NF-κB 介导的活性。在这篇综述中，我们重点强调了 KLF2 在健康和疾病状态中的作用，以及它们如何与转录主调控因子 NF-κB 相互作用。
Int J Mol Sci. 2017-11-10
Proc Natl Acad Sci U S A. 2006-4-25
Biochemistry (Mosc). 2020-1
Arterioscler Thromb Vasc Biol. 2006-5
MedComm (2020). 2025-7-25
Biomedicines. 2025-4-8
Theranostics. 2025-2-18
Am J Respir Crit Care Med. 2017-3-1
Nat Commun. 2016-1-5
Front Immunol. 2014-10-20
Arterioscler Thromb Vasc Biol. 2015-1
Zotero 插件