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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.

作者信息

Zhang Qian, Lenardo Michael J, Baltimore David

机构信息

Department of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.

Molecular Development of the Immune System Section and NIAID Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Cell. 2017 Jan 12;168(1-2):37-57. doi: 10.1016/j.cell.2016.12.012.

DOI:10.1016/j.cell.2016.12.012
PMID:28086098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5268070/
Abstract

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

摘要

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本文引用的文献

[1]
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell. 2016-8-25

[2]
A Japanese family case with juvenile onset Behçet's disease caused by TNFAIP3 mutation.

Allergol Int. 2017-1

[3]
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.

Am J Hum Genet. 2016-8-4

[4]
NF-κB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation.

J Clin Immunol. 2016-8

[5]
Deficiency in Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1: A Novel Cause of IPEX-Like Syndrome.

J Pediatr Gastroenterol Nutr. 2017-3

[6]
Cutaneous cylindroma: it's all about MYB.

J Pathol. 2016-7-11

[7]
Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease.

RMD Open. 2016-5-5

[8]
Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies.

Curr Opin Hematol. 2016-7

[9]
Poly-ubiquitination in TNFR1-mediated necroptosis.

Cell Mol Life Sci. 2016-6

[10]
The CYLD p.R758X worldwide recurrent nonsense mutation detected in patients with multiple familial trichoepithelioma type 1, Brooke-Spiegler syndrome and familial cylindromatosis represents a mutational hotspot in the gene.

BMC Genet. 2016-2-9

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