Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Acta Obstet Gynecol Scand. 2018 Mar;97(3):248-257. doi: 10.1111/aogs.13259. Epub 2017 Dec 11.
Women with a history of placenta-related pregnancy complications, such as preeclampsia, intrauterine growth restriction or preterm delivery, have an increased risk for recurrence of such complications. This recurrence is likely the result of underlying endothelial dysfunction that leads to abnormal placentation, especially in complications with an early onset. This study provides an overview of biomarkers of placental development and function in pregnancies from women with a history of placenta-related complications.
A systematic literature search was conducted limited to human studies and including keywords related to a history of placenta-related complications and markers of placental development and function. Two independent reviewers assessed eligibility and quality of 1553 retrieved unique articles.
Five articles reporting on placental development and function in women with an obstetric history of preeclampsia (n = 3), intrauterine growth restriction (n = 1) and preterm delivery (n = 2) were eligible for quality assessment. We identified associations between a history of preeclampsia and abnormal placental histological findings at term in the current pregnancy, but found contradictory results regarding presence of uterine artery notching. In women with a history of very preterm delivery (<32 weeks), one study showed associations with abnormal placental histology.
Literature on the association between a history of placenta-related complications and placental development and function in subsequent pregnancies is scarce and studies are heterogeneous. However, literature shows that placenta-related pregnancy complications are associated with subsequent placental histology.
有胎盘相关妊娠并发症史的女性，如子痫前期、宫内生长受限或早产，再次发生此类并发症的风险增加。这种复发可能是潜在的血管内皮功能障碍导致胎盘异常的结果，尤其是在发病较早的并发症中。本研究综述了有胎盘相关并发症史的孕妇的胎盘发育和功能的生物标志物。
对与胎盘相关并发症史和胎盘发育和功能标志物相关的关键词进行了系统的文献检索，仅限于人类研究。两位独立的审查员评估了 1553 篇独特文章的入选标准和质量。
有 5 篇关于子痫前期（n=3）、宫内生长受限（n=1）和早产（n=2）产科史女性胎盘发育和功能的文章符合质量评估标准。我们发现，子痫前期史与当前妊娠足月时胎盘组织学异常之间存在关联，但在子宫动脉切迹的存在方面存在矛盾的结果。在有极早产史（<32 周）的女性中，一项研究显示与胎盘组织学异常存在关联。
关于胎盘相关并发症史与后续妊娠中胎盘发育和功能之间的关联的文献很少，且研究具有异质性。然而，文献表明，与胎盘相关的妊娠并发症与随后的胎盘组织学有关。
