Sigma54 启动子的隐藏秘密被揭示。
Hidden Secrets of Sigma54 Promoters Revealed.
机构信息
Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
出版信息
Trends Biochem Sci. 2017 Dec;42(12):931-932. doi: 10.1016/j.tibs.2017.10.005. Epub 2017 Nov 7.
Bacterial sigma54 (σ) promoters are the DNA-binding motif for σ-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation.
细菌 σ54（σ）启动子是含 σ 的 RNA 聚合酶（RNAP）全酶的 DNA 结合基序。最近的一项研究使用了合成寡核苷酸文库筛选、生化特性分析和生物信息学相结合的方法，揭示了 σ 启动子的一个新的、意想不到的作用，即编码一种细菌“绝缘子序列”，以抑制不必要的翻译。
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