Zanandrea Rodrigo, Abreu Murilo S, Piato Angelo, Barcellos Leonardo J G, Giacomini Ana C V V
Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.
Neurosci Lett. 2018 Jan 18;664:34-37. doi: 10.1016/j.neulet.2017.11.010. Epub 2017 Nov 7.
We examined whether lithium carbonate (LiCO, 100mg/L) is able to prevent memory impairment induced by scopolamine. Moreover, we evaluated the effects of lithium on anxiety-like behavior and acetylcholinesterase activity in adult zebrafish. We demonstrated that lithium prevents the memory impairment induced by scopolamine, decreases exploration and increases the activity of acetylcholinesterase in zebrafish. Collectively, this contributes to a better understanding of the pharmacology of lithium, its interaction with cholinergic neurotransmission, and its possible application to therapeutic treatments aimed at improving cognition.
我们研究了碳酸锂（LiCO，100mg/L）是否能够预防东莨菪碱诱导的记忆损伤。此外，我们评估了锂对成年斑马鱼焦虑样行为和乙酰胆碱酯酶活性的影响。我们证明，锂可预防东莨菪碱诱导的记忆损伤，减少探索行为，并增加斑马鱼体内乙酰胆碱酯酶的活性。总的来说，这有助于更好地理解锂的药理学、其与胆碱能神经传递的相互作用，以及其在旨在改善认知的治疗中的可能应用。
