Dvořáčková Simona, Ládová Kateřina, Malý Josef, Kolář Jozef, Penka Miroslav
Vnitr Lek. 2017 Fall;63(10):633-639.
Medication adherence is a complex problem reflecting variations in terms of medication taking behavior. It is essential in maximizing of the effect and risk minimization of the therapy and health care costs reduction, even in the case of oral anticoagulants (non-vitamin K antagonist oral anticoagulants - NOACs). The aim of this paper was to review the published literature and to discuss results in the field of medication adherence to NOACs in patients with non-valvular atrial fibrillation (NVAF). Based on the searching in databases Embase and PubMed 25 studies were identified, of which conclusions were summarized in this paper. Patients treated with dabigatran reported poorer medication adherence than patients with rivaroxaban. However, medication adherence is influenced by many circumstances as well as included studies were not sufficiently uniform, therefore, a prerequisite for further investigation of this issue is expected.Key words: apixaban - atrial fibrillation - dabigatran - medication adherence - patient compliance - rivaroxaban.
药物依从性是一个复杂的问题，反映了服药行为方面的差异。即使在口服抗凝剂（非维生素K拮抗剂口服抗凝剂 - NOACs）的情况下，它对于最大化治疗效果、最小化风险以及降低医疗保健成本也至关重要。本文的目的是回顾已发表的文献，并讨论非瓣膜性心房颤动（NVAF）患者对NOACs药物依从性领域的研究结果。通过在Embase和PubMed数据库中检索，确定了25项研究，本文总结了这些研究的结论。接受达比加群治疗的患者报告的药物依从性比接受利伐沙班治疗的患者差。然而，药物依从性受到多种情况的影响，而且纳入的研究不够统一，因此，预计对该问题进行进一步研究的一个先决条件。关键词：阿哌沙班 - 心房颤动 - 达比加群 - 药物依从性 - 患者依从性 - 利伐沙班。
