肺移植后原发性移植物功能障碍。
Primary Graft Dysfunction After Lung Transplantation.
机构信息
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
出版信息
Clin Chest Med. 2017 Dec;38(4):641-654. doi: 10.1016/j.ccm.2017.07.005. Epub 2017 Sep 20.
Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of inflammatory cytokines and chemokines. This article reviews the epidemiology, pathogenesis, risk factors, prevention, and treatment of primary graft dysfunction.
原发性移植物功能障碍是肺移植后发生的一种急性损伤，与显著的短期和长期发病率和死亡率相关。多种机制导致原发性移植物功能障碍的发病机制，包括缺血再灌注损伤、上皮细胞死亡、内皮细胞功能障碍、固有免疫激活、氧化应激以及炎症细胞因子和趋化因子的释放。本文综述了原发性移植物功能障碍的流行病学、发病机制、危险因素、预防和治疗。
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