Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94304, USA.
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94304, USA.
Clin Liver Dis. 2018 Feb;22(1):133-140. doi: 10.1016/j.cld.2017.08.010. Epub 2017 Oct 21.
Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are highly prevalent, affecting approximately one-third of the US population. The relationship between NAFLD and MS is complex and may be bidirectionally associated. NAFLD is strongly associated with MS, the components of which include abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. NAFLD associated with certain genetic factors such as the PNPLA3 G allele variant is not accompanied by insulin resistance and MS. Lifestyle modification, including diet and physical activity targeting visceral adiposity, remains the standard of care for patients with NAFLD and MS.
非酒精性脂肪性肝病（NAFLD）和代谢综合征（MS）的患病率很高，大约影响了美国三分之一的人口。NAFLD 和 MS 之间的关系很复杂，可能是双向关联的。NAFLD 与 MS 密切相关，其组成部分包括腹部肥胖、高血糖、高血压和血脂异常。与某些遗传因素相关的 NAFLD，如 PNPLA3 G 等位基因变异，并不伴有胰岛素抵抗和 MS。生活方式的改变，包括针对内脏肥胖的饮食和体育活动，仍然是 NAFLD 和 MS 患者的标准治疗方法。
