非酒精性脂肪性肝病/非酒精性脂肪性肝炎的诊断和评估，包括无创生物标志物和瞬时弹性成像。
Diagnosis and Evaluation of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Noninvasive Biomarkers and Transient Elastography.
机构信息
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tulane Medical Center, 1430 Tulane Avenue, SL 35, New Orleans, LA 70119, USA.
Department of Internal Medicine, Division of Hepatology, Sandra A. Bass Center of Liver Diseases Northwell Health, 400 Community Drive, Manhasset, NY 11030, USA.
出版信息
Clin Liver Dis. 2018 Feb;22(1):73-92. doi: 10.1016/j.cld.2017.08.004.
The incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) are increasing and identification of people at risk of disease progression is extremely important. The current gold standard for diagnosing NAFLD/nonalcoholic steatohepatitis (NASH) is by liver biopsy, but it has several limitations. Noninvasive tests via biomarkers and transient elastography to assess NAFLD/NASH are being used in clinical practice. The most validated diagnostic panels include the NAFLD fibrosis score, FIB-4 (Fibrosis-4), and FibroMeter. Transient elastography is very useful in evaluating advanced fibrosis and cirrhosis.
非酒精性脂肪性肝病（NAFLD）的发病率和患病率正在上升，因此识别疾病进展风险人群极其重要。目前，诊断 NAFLD/非酒精性脂肪性肝炎（NASH）的金标准是肝活检，但它有几个局限性。通过生物标志物和瞬时弹性成像进行的非侵入性检测用于评估 NAFLD/NASH 正在临床实践中使用。最有效的诊断组合包括 NAFLD 纤维化评分、FIB-4（纤维化-4）和 FibroMeter。瞬时弹性成像在评估晚期纤维化和肝硬化方面非常有用。
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