Kroft Steven H, Harrington Alexandra M
Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Clin Lab Med. 2017 Dec;37(4):697-723. doi: 10.1016/j.cll.2017.07.001. Epub 2017 Aug 31.
Flow cytometric evaluation is considered a standard ancillary study for the diagnosis of most B-cell lymphoproliferative disorders. Establishing a neoplastic B-cell population depends on identification of light chain restriction or lack of light chain expression in mature neoplasms and demonstration of aberrant antigen expression in both immature and mature neoplasms, as compared with normal counterparts. The immunophenotypes of the most common B-cell neoplasms are herein described, with an emphasis on their immunophenotypic differential diagnosis and prognostic and therapeutic implications.
流式细胞术评估被认为是诊断大多数B细胞淋巴增殖性疾病的标准辅助研究。确定肿瘤性B细胞群体取决于在成熟肿瘤中识别轻链限制或轻链表达缺失，以及与正常对应物相比，在未成熟和成熟肿瘤中证明异常抗原表达。本文描述了最常见B细胞肿瘤的免疫表型，重点是它们的免疫表型鉴别诊断以及对预后和治疗的影响。
