儿科造血系统恶性肿瘤中的流式细胞术

Flow Cytometry in Pediatric Hematopoietic Malignancies.

作者信息

Li Jie, Wertheim Gerald, Paessler Michele, Pillai Vinodh

机构信息

Department of Pathology and Laboratory Medicine, Division of Hematopathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Hospital of University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Department of Pathology and Laboratory Medicine, Division of Hematopathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

出版信息

Clin Lab Med. 2017 Dec;37(4):879-893. doi: 10.1016/j.cll.2017.07.009. Epub 2017 Sep 28.

DOI:10.1016/j.cll.2017.07.009

PMID:29128074

Abstract

Utility of flow cytometry in the evaluation of pediatric hematopoietic neoplasms and the differences from adult hematopoietic neoplasms are discussed in this review. Distinction of hematogones from B-lymphoblasts, detection of residual/relapsed disease after novel targeted therapies, and evaluation of pediatric myeloid neoplasms are discussed.

摘要

本文综述了流式细胞术在儿科造血肿瘤评估中的应用以及与成人造血肿瘤的差异。讨论了造血细胞与B淋巴细胞母细胞的鉴别、新型靶向治疗后残留/复发性疾病的检测以及儿科髓系肿瘤的评估。