Dewdney Brittany, Trollope Alexandra, Moxon Joseph, Thomas Manapurathe Diana, Biros Erik, Golledge Jonathan
The Vascular Biology Unit, Queensland Research Centre for Peripheral Arterial Diseases, College of Medicine & Dentistry, James Cook University, Townsville, Queensland, Australia.
The Vascular Biology Unit, Queensland Research Centre for Peripheral Arterial Diseases, College of Medicine & Dentistry, James Cook University, Townsville, Queensland, Australia; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia.
J Stroke Cerebrovasc Dis. 2018 Mar;27(3):522-530. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.058. Epub 2017 Nov 8.
Acute ischemic stroke is a leading cause of death and disability worldwide. Unlike myocardial infarction, there is no current blood test to diagnose acute ischemic stroke. MicroRNAs (miRNAs) are very stable in the blood and have been suggested as potential diagnostic markers.
This review aimed to systematically assess case-control studies investigating the association of circulating miRNAs with acute ischemic stroke. Medline, CINAHL, Cochrane Library, Web of Science, Scopus, and PubMed were searched for studies that examined the association of circulating miRNAs in patients with acute ischemic stroke. Studies meeting specific inclusion and exclusion criteria (such as blood samples obtained within 24 hours of an acute ischemic stroke) were selected for data extraction. Two authors extracted data from the included studies relevant to the study design, the patient characteristics, and the relative miRNA expression.
Eight studies were included involving 572 cases and 431 healthy controls. Twenty-two miRNAs (12 upregulated and 10 downregulated) were reported as differentially expressed. Only 1 miRNA, miR-106b, was reported as differentially expressed in at least 2 studies. Significant heterogeneity in the design and methods of the included studies was noted.
Differential expression of a large number of miRNAs has been reported early following acute ischemic stroke. More research is required in larger patient populations to further evaluate the diagnostic potential of the reported miRNAs.
急性缺血性卒中是全球范围内导致死亡和残疾的主要原因。与心肌梗死不同，目前尚无用于诊断急性缺血性卒中的血液检测方法。微小RNA（miRNA）在血液中非常稳定，已被认为是潜在的诊断标志物。
本综述旨在系统评估调查循环miRNA与急性缺血性卒中关联的病例对照研究。检索了Medline、CINAHL、Cochrane图书馆、Web of Science、Scopus和PubMed，以查找研究急性缺血性卒中患者循环miRNA关联的研究。选择符合特定纳入和排除标准（如在急性缺血性卒中24小时内采集的血样）的研究进行数据提取。两位作者从纳入研究中提取与研究设计、患者特征和相对miRNA表达相关的数据。
纳入八项研究，涉及572例病例和431名健康对照。报告了22种miRNA（12种上调和10种下调）差异表达。只有1种miRNA，即miR-106b，在至少两项研究中被报告为差异表达。注意到纳入研究的设计和方法存在显著异质性。
急性缺血性卒中后早期已报告大量miRNA差异表达。需要在更大的患者群体中进行更多研究，以进一步评估所报告miRNA的诊断潜力。
